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HEMI-Link™ Chemistry & Technology
JE PolyDesign (JEPD) is a supplier of the highest purity products available in the marketplace of 2-Hydroxyethylmaleimide (99.5+%), and derivatives thereof. This is the HEMI-Link™-Technology platform:
2-Hydroxyethylmaleimide (HEMI) HEMI-Link™-Derivatives
R provides:
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Chemical design opportunities
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Reactive functionalities
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Designed chemical/pH stability
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Hydrophilic or Hydrophobic character
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Multi functional are crosslinking agents
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Photo-labeling
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"Your Target"?
We provide 20+ years of unique experience and well-documented knowledge from designing maleimide-based linkers, building blocks, and reactive intermediates for targeted applications.
Bioconjugation and Antibody Drug Conjugates (ADC's)
Building blocks from 2-Hydroxyethylmaleimide, and its derivatives, are exceptionally suitable for bioconjugation techniques, as an example applied for "Antibody-Drug Conjugate" (ADC) chemistries (JEPD patent pending). Below is a simplistic and schematic illustration of how 2-Hydroxyethylmaleimide could be used as linker between cytotoxic warheads (aka payloads) with antibodies to form ADC's:
The chemical and pH-stability of the ADC products are critical for all applications and medical treatments based on ADC chemistry. HEMI-Link™-Technology has the chemical tools to address and design targeted properties, such as controlled release of the drugs. One big challenge is to design ADC's with bioorthogonal characteristics, and to minimize damaging de-conjugation of the ADC in the blood-stream before the drug reaches the targeted cancer cells. Conclusively, there is an immediate need for novel and designed linker chemistry to support near future developments of ADC's suitable for oncological therapeutics. JEPD provides one "tool box" for this purpose, which is the HEMI-Link™-Technology platform.
Affinity Ligands for Chromatography
2-Hydroxyethylmaleimide and derivatives thereof are also very suitable for the design of affinity ligands. Chromatography, purification, analysis, and separation media techniques are already, since many years, utilizing maleimide-based affinity ligands for practical applications to purify biomolecules, such as for example proteins and pharmaceuticals, etc. Maleimides from JEPD provide an excellent and enabling tool for these applications to develop new, more pure, designed, and efficient products. Below is a schematic illustration of how an affinity ligand prepared from 2-Hydroxyethylmaleimide, or its derivatives, would be linked to a solid support such as chromatographic beads:
If your company or research project need new, innovative, and enabling chemistry based on 2-Hydroxyethylmaleimide, or related products and chemistries, for any field of application, then look no further!
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Highest purity and quality available
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Consistent and timely delivery
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Satisfaction guaranteed
2-Hydroxyethylmaleimide (HEMI) and its derivatives polymerizes by free-radical and/or charge-transfer induced polymerization, and;
HEMI-Link™-Products are:
Sulfhydryl reactive
Specific affinity ligands
Efficient Michael acceptors
Labeling agents for biomolecules
Building blocks for bioconjugation
Antibody-Drug Conjugate (ADC) Linkers
Having unique photochemical characteristics
Suitable for advanced surface and coatings design
Crosslinkers if multiple maleimide groups are present
Used for chromatographpy and separation media design
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